One of the most annoying things in the world is Carol Teitel's old lady voice, aside from her normal voice.  Of course, the horrible cat and dog sounds and irritating horns on CBSRMT are maddening, and this voice is also like nails on a chalkboard.  I can tolerate Mercedes McCambridge (although I really do avoid some of her episodes), Catherine Byers, Leon Janney, and so on, because the shows are usually so entertaining that I can deal with it.  